Koeppen And Stanton Renal Physiology Pdf 13

In the future, a more in-depth review of the renal epithelial systems and ECM, as well as renal cell culture models, could facilitate the development of more refined and accurate models for the kidney.

Renal clearance is an important route of drug elimination from the bloodstream, mainly facilitated by the proximal tubule, which renders proximal tubule epithelial cells prone to drug-induced kidney injury. Mimicking the in vivo environment by including extracellular matrix (ECM) components, three-dimensional (3D) architectural features, a heterogeneous cellular composition and incorporating fluid shear stress in an in vitro kidney model could improve prediction of injury after drug exposures.

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Koeppen And Stanton Renal Physiology Pdf 13

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